The Giant Has Hidden His Heart

Hereditary Gigantism-the biblical giant Goliath and his brothers

The biblical giant Goliath has an identifiable family tree suggestive of autosomal dominant inheritance. We suggest that he had a hereditary pituitary disorder possibly due to the AIP gene, causing early onset and familial acromegaly or gigantism. We comment on the evidence within the scriptures for his other relatives including a relative with six digits and speculate on possible causes of the...

Deepak Srivastava: follows his heart to study the heart.

"his Heart Exposed to Prying Eyes, to Pity Has No Claim": Reflections on Hogarth and the Nature of Crueltv

In his famous discussion of the source of our duties concerning anirrals, the German philosopher Immanuel Kant approvingly mentions a series of engravings ( "The Four Stages of Cruelty") by the English artist William Hogarth as exemplifying one of his central contentions. [2] The approach to our duties regarding anirrals advocated by Kant holds that avoiding cruelty is the most fUndamental duty...

Lactobacillus Paracasei Has Anti-Inflammatory Effect on the Heart Failure Induced by Isoproterenol in Rats

Background: Heart failure (HF) has become one of the most prevalent cardiovascular problems worldwide. Considering the beneficial effects of probiotics on human health, we aimed to investigate the anti-inflammatory effect of oral administration of Lactobacillus paracasei in HF induced by isoproterenol. Methods: Forty Wistar male rats weighing 80g on average were randomly assigned to five grou...

Infra-His Block in a Normal Heart

A 55 year old man with history of palpitation was referred for electrophysiologic study. Baseline ECG, physical examination and transthoracic echocardiographic study were normal. Electrophysiologic study revealed normal AH and HV intervals. Pacing of right atrium with a cycle length of 300 msec showed 2:1 AV block. AH interval was 252 msec and the block was infra-his (Figure 1). With continual ...